TL;DR:
T4 is your storage hormone. T3 is your active regulator. T2 (3,5-diiodo-L-thyronine) is the overlooked metabolic accelerator that helps your cells burn energy efficiently.
Quick Comparison
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T4 (Thyroxine): Storage form produced by the thyroid gland. Must convert into T3 or T2 to become active.
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T3 (Triiodothyronine): Active hormone that regulates energy use, temperature, and metabolism.
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T2 (3,5-Diiodo-L-thyronine): Acts directly on mitochondria to support fat oxidation and energy production.
How T2 Supports Metabolism
T2 interacts with mitochondria—your body’s energy factories—to support fat oxidation and energy output. It may explain why some people have sluggish metabolism even when T3 and T4 appear “normal.”
Why T2 Is Overlooked
T2 isn’t measured on standard lab panels. Most people and even many clinicians focus on TSH, T4, and T3. Yet, many lingering symptoms of fatigue, cold intolerance, and low motivation stem from energy metabolism—where T2 plays a key role.
Ways to Support Healthy Thyroid Metabolism
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Cover nutrient cofactors like selenium, zinc, iodine, and tyrosine.
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Manage stress and prioritize sleep to aid hormone conversion.
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Support liver health and maintain steady protein intake.
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Consider comprehensive thyroid-metabolism support that includes nutrients and adaptogens designed to promote efficient conversion and energy production.
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Add in Thyroid Fixxr or Metabolism Fixxr to add in T2
Informational only. Not medical advice. Consult your healthcare provider before starting any supplement.